Gene
ptpn12
- ID
- ZDB-GENE-040426-1441
- Name
- protein tyrosine phosphatase non-receptor type 12
- Symbol
- ptpn12 Nomenclature History
- Previous Names
-
- zgc:65856
- zgc:77437
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in colorectal cancer. Is expressed in several structures, including immature eye; nervous system; neural tube; pectoral fin musculature; and pleuroperitoneal region. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65856 (6 images)
- MGC:77437 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Duffy et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colon cancer, somatic | 114500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR047251 | Protein-tyrosine phosphatase non-receptor type-12, catalytic domain |
| Family | IPR012266 | Tyrosine-protein phosphatase non-receptor type 12 |
| Family | IPR047170 | Tyrosine-protein phosphatase non-receptor type 12/18/22 |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Length | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase non-receptor type-12, catalytic domain | Tyrosine-protein phosphatase non-receptor type 12 | Tyrosine-protein phosphatase non-receptor type 12/18/22 | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PEI4
|
570 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn12-201
(1)
|
Ensembl | 510 nt |
Interactions and Pathways
No data available
Plasmids
No data available